RENAL BIOPSY (LIGHT MICROSCOPY / HISTOPATHOLOGY ONLY)

NB (!): Detailed clinical information is required e.g. 1. Indication (e.g., suspected tumor, nephrotic syndrome, nephritic syndrome, CKD etc.), relevant diagnostic findings [e.g. imaging, serum creatinine, urinalysis (protein, RBCs, casts), serum albumin, complement (C3, C4), autoantibodies (ANA, dsDNA, ANCA, anti-GBM), HBV/ HCV/ HIV status etc.]. For NON-TUMOR (MEDICAL KIDNEY) indications, RENAL BIOPSY COMPREHENSIVE EVALUATION (LIGHT MICROSCOPY + IMMUNOFLUORESCENCE) is advised instead. 2. Transplant status i.e. native (no transplant) vs. transplant kidney. 3. Relevant medications within last 3-6 months. SAMPLE TYPE: Renal (kidney) core biopsy in 10% NEUTRAL BUFFERED FORMALIN. SPECIMEN PROCESSING & PRESERVATION (SPECIMEN ALLOCATION IS CRITICAL): Core in 10% NEUTRAL BUFFERED FORMALIN (volume at least 10x the tissue volume) for LIGHT MICROSCOPY (LM). STORAGE & SHIPPING: • Storage: Specimens should be kept at room temperature. Do NOT freeze or refrigerate, as freezing lyses cells and ice crystal formation destroys architecture. • Shipping temperature: ship at ambient temperature (15-25°C) via overnight courier to ensure delivery within 24 hours of biopsy. STABILITY: Tissue stability is indefinite in 10% neutral buffered formalin once adequate fixation has occurred.