Category
SPECIAL CHEMISTRY.
Sub Category
AUTOIMMUNE
Synonyms/Aliases
MYASTHENIA GRAVIS ANTIBODY; ACHR BINDING ANTIBODY.
Abbreviations
ACHR
Type
INDIVIDUAL TEST
Results
RESULTS READY/ REPORTED IN 5 WORKING DAYS
Method
RADIOIMMUNOASSAY (RIA)
Temp
REFRIGERATED.
Setup
BATCHED.
Components Parameters
NOT APPLICABLE.
PRE-ANALYTIC CONSIDERATIONS
Test Ordering Instructions
FILL OUT TEST REQUEST FORM FULLY & LEGIBLY. AVOID USE OF ANAESTHETIC OR MUSCLE RELAXANT 24HRS PRIOR TO SAMPLING.
Patient preparation
AVOID GENERAL ANAESTHETIC/ MUSCLE RELAXANT FOR 24HRS PRIOR TO SAMPLE COLLECTION.
Sample type
SERUM
Container/ preservative
SERUM SEPARATOR TUBE (SST/ GEL) OR PLAIN (RED TOP) VACUTAINER.
Sample volume
10ML ALIQUOT OF 24 HOUR URINE. ORIGINAL (TOTAL) VOLUME IN ML MUST BE SPECIFIED ON THE REQUEST FORM.
Rejection criteria
LABELING ISSUE (UNLABELED/ MISLABELED); MISSING REQUEST FORM; MISMATCH BETWEEN REQUEST FORM & SAMPLE DETAILS; MISSING AGE/ GENDER; WRONG SAMPLE TYPE; INSUFFICIENT SAMPLE.
Other Instructions
CENTRIFUGE SST (SERUM GEL TUBES) WITHIN 1-2 HOURS OF COLLECTION. CENTRIFUGE RED TOP VACUTAINERS AND ALIQUOT SERUM WITHIN 1-2 HOURS OF COLLECTION. THE SEPARATION VIAL MUST BE LABELED WITH AT LEAST 2 PATIENT IDENTIFIERS AND THE SAMPLE TYPE.
Reference intervals
INTERPRETIVE DATA IS PROVIDED ON THE REPORT.
Clinical Utility
HIGHLY SPECIFIC FOR MYASTHENIA GRAVIS. USED TO DISTINGUISH MYASTHENIA GRAVIS FROM OTHER CONDITIONS WITH SIMILAR SYMPTOMS.
Test Limitations/ Confounders
10-15% OF PATIENTS WITH GENERALIZED MYASTHENIA GRAVIS AND 25-50% OF PATIENTS WITH OCULAR MYASTHENIA ARE SERONEGATIVE FOR ACHR.