Category
SPECIAL CHEMISTRY.
Sub Category
ENDOCRINE
Synonyms/Aliases
COSYNTROPIN TEST; SYNACTHEN TEST
Abbreviations
- N/A
Type
PROFILE/ PANEL (BUNDLED TESTS)
Results
RESULTS READY/ REPORTED IN 7 WORKING DAYS
Method
IMMUNOASSSAY
Temp
REFRIGERATED.
Setup
BATCHED.
Components Parameters
CORTISOL TESTING ON 0 MINUTE, 30 MINUTE & 60 MINUTE SAMPLES.
PRE-ANALYTIC CONSIDERATIONS
Test Ordering Instructions
FILL OUT TEST REQUEST FORM FULLY & LEGIBLY. PATIENT SHOULD DISCONTINUE STEROIDS AT LEAST 24 HOURS PRIOR TO THE TEST.
Patient preparation
MULTI-SAMPLING WILL BE DONE I.E. BASAL CORTISOL AT 8-9A.M. (PRIOR TO DRUG ADMINISTRATION), THEN 30 MINUTES & 60 MINUTES POST COSYNTROPIN ADMINISTRATION (250 MICROGRAMS ADMINISTERED IM OR IV). CONSENT NEEDED
Sample type
THREE SERUM SAMPLES [BASAL (0 MIN), 30 MIN & 60 MIN]. SAMPLE LABEL MUST INCLUDE COLLECTION SEQUENCE I.E. 0 MIN, 30 MIN & 60 MIN
Container/ preservative
THREE SERUM SEPARATOR TUBES (SST/ GEL) OR PLAIN (RED TOP) VACUTAINERS.
Sample volume
3 ML
Rejection criteria
LABELING ISSUE (UNLABELED/ MISLABELED/ COLLECTION SEQUENCE NOT STATED); MISSING REQUEST FORM; MISMATCH BETWEEN REQUEST FORM & SAMPLE DETAILS; MISSING AGE/ GENDER; WRONG SAMPLE TYPE; INSUFFICIENT SAMPLE.
Other Instructions
CENTRIFUGE SST (SERUM GEL TUBES) WITHIN 1-2 HOURS OF COLLECTION. CENTRIFUGE RED TOP VACUTAINERS AND ALIQUOT SERUM WITHIN 1-2 HOURS OF COLLECTION. THE SEPARATION VIAL MUST BE LABELED WITH AT LEAST 2 PATIENT IDENTIFIERS AND THE SAMPLE TYPE.
Reference intervals
INTERPRETIVE DATA IS PROVIDED ON THE REPORT.
Clinical Utility
THIS IS AN ENDOCRINE STIMULATION TEST USED WHEN EVALUATING FOR ADRENAL INSUFFICIENCY (ADDISON'S DISEASE). ADMINISTRATION OF SYNTHETIC ACTH (COSYNTROPIN) SHOULD RESULT IN SUFFICIENT PRODUCTION OF CORTISOL BY THE ADRENAL GLAND.
Test Limitations/ Confounders
INCORRECT LABELING OF COLLECTION SEQUENCE WILL RESULT IN INACCURATE INTERPRETATION.