Category
SEROLOGY/ IMMUNOLOGY
Sub Category
AUTOIMMUNE
Synonyms/Aliases
CARDIOLIPIN ANTIBODIES; ANTIPHOSPHOLIPID ANTIBODIES.
Abbreviations
ACA; ACL Ab; ACA IgG, IgM.
Type
PROFILE/ PANEL (BUNDLED TESTS).
5 days
5 WORKING DAYS
Method
IMMUNOASSAY.
Temp
AMBIENT (6 HOURS), REFRIGERATED (7 DAYS), FROZEN (14 DAYS)
Setup
BATCHED.
Components Parameters
ACA IgG, ACA IgM.
PRE-ANALYTIC CONSIDERATIONS
Test Ordering Instructions
FILL OUT TEST REQUEST FORM FULLY & LEGIBLY.
Patient preparation
N/A.
Sample type
SERUM
Container/ preservative
SERUM SEPARATOR TUBE (SST/ GEL) OR PLAIN (RED TOP) VACUTAINER.
Sample volume
2ML.
Rejection criteria
LABELING ISSUE (UNLABELED/ MISLABELED); MISSING REQUEST FORM; MISMATCH BETWEEN REQUEST FORM & SAMPLE DETAILS; MISSING AGE/ GENDER; WRONG SAMPLE TYPE; INSUFFICIENT SAMPLE; HEMOLYZED, LIPEMIC, ICTERIC SAMPLES.
Other Instructions
N/A.
Reference intervals
NEGATIVE.
Clinical Utility
EVALUATION OF ANTIPHOSPHOLIPID SYNDROME (PHOSPHOLIPID ANTIBODY SYNDROME). EVALUATION OF PATIENTS WITH UNEXPLAINED THROMBOSIS, RECURRENT MISCARRIAGES ETC.
Test Limitations/ Confounders
POSITIVE RESULTS MAY OCCUR IN OTHER AUTOIMMUNE DISORDERS E.G. SLE, RHEUMATOID ARTHRITIS, SJOGREN'S SYNDROME & IN THESE CONDITIONS MAY BE ASSOCIATED WITH INCREASED THROMBOTIC RISK. TRANSIENT POSITIVITY CAN OCCUR AND REPEAT TESTING IS ADVISED AFTER 12 WEEKS TO DEMONSTRATE PERSISTENCE OF ANTIBODIES.