Category
SPECIAL CHEMISTRY.
Sub Category
ENDOCRINE
Synonyms/Aliases
CONNECTING PEPTIDE OF INSULIN
Abbreviations
-N/A
Type
INDIVIDUAL TEST
Results
RESULTS READY/ REPORTED 7 WORKING DAYS
Method
IMMUNOASSAY
Temp
FROZEN (PREFERRED) OR REFRIGERATED. LIMITED STABILITY AT AMBIENT (ROOM) TEMPERATURE WHICH SHOULD BE AVOIDED.
Setup
BATCHED.
Components Parameters
NOT APPLICABLE
PRE-ANALYTIC CONSIDERATIONS
Test Ordering Instructions
FILL OUT TEST REQUEST FORM FULLY & LEGIBLY. HISTORY REQUIRED.
Patient preparation
OVERNIGHT FASTING (8-12HRS). FASTING MEANS THAT ONLY WATER AND PRESCRIBED MEDICATION ARE PERMITTED DURING THE FASTING PERIOD.
Sample type
SERUM
Container/ preservative
SERUM SEPARATOR TUBE (SST/ GEL) OR PLAIN (RED TOP) VACUTAINER.
Sample volume
AT LEAST 2ML.
Rejection criteria
LABELING ISSUE (UNLABELED/ MISLABELED); MISSING REQUEST FORM; MISMATCH BETWEEN REQUEST FORM & SAMPLE DETAILS; MISSING AGE/ GENDER; WRONG SAMPLE TYPE; INSUFFICIENT SAMPLE; AMBIENT TEMPERATURE. NON-FASTING SAMPLES.
Other Instructions
CENTRIFUGE SST (SERUM GEL TUBES) WITHIN 1-2 HOURS OF COLLECTION. CENTRIFUGE RED TOP VACUTAINERS AND ALIQUOT SERUM WITHIN 1-2 HOURS OF COLLECTION. THE SEPARATION VIAL MUST BE LABELED WITH AT LEAST 2 PATIENT IDENTIFIERS AND THE SAMPLE TYPE.
Reference intervals
AGE & GENDER APPROPRIATE VALUES ARE PROVIDED ON THE REPORT.
Clinical Utility
EVALUATION OF PANCREATIC BETA CELL FUNCTION (E.G. TO DISTINGUISH TYPE 1 VS. TYPE 2 DIABETES). WORK UP OF HYPERINSULINEMIC HYPOGLYCEMIA (E.G. DIFFERENTIATE BETWEEN FACTITIOUS HYPOGLYCEMIA & POSSIBLE INSULINOMAS). C-PEPTIDE IS CO-PRODUCED WITH ENDOGENOUS INSULIN & IS THEREFORE A USEFUL MARKER OF INSULIN PRODUCTION.
Test Limitations/ Confounders
IMMUNOASSAY INTERFERENCE CAN GIVE RISE TO SPURIOUS RESULTS. SUCH INTERFERENCE CAN ARISE FROM PRESENCE OF HETEROPHILE ANTIBODIES, ANTI-ANIMAL ANTIBODIES, AUTOANTIBODIES, PARAPROTEINS, BIOTIN ETC. RESULTS SHOULD ALWAYS BE CORRELATED WITH CLINICAL FINDINGS.