Category
SPECIAL CHEMISTRY.
Sub Category
TUMOR MARKER
Synonyms/Aliases
CARBOHYDRATE ANTIGEN 125
Abbreviations
CA 125
Type
INDIVIDUAL TEST
Results
RESULTS READY/ REPORTED IN 3-4 HRS
Method
IMMUNOASSAY
Temp
ROOM TEMPERATURE
Setup
BATCHED.
Components Parameters
NOT APPLICABLE
PRE-ANALYTIC CONSIDERATIONS
Test Ordering Instructions
FILL OUT TEST REQUEST FORM FULLY & LEGIBLY.
Patient preparation
NO PREPARATION REQUIRED
Sample type
SERUM
Container/ preservative
SERUM SEPARATOR TUBE (SST/ GEL) OR PLAIN (RED TOP) VACUTAINER.
Sample volume
AT LEAST 2ML
Rejection criteria
LABELING ISSUE (UNLABELED/ MISLABELED); MISSING REQUEST FORM; MISMATCH BETWEEN REQUEST FORM & SAMPLE DETAILS; MISSING AGE/ GENDER; WRONG SAMPLE TYPE; INSUFFICIENT SAMPLE.
Other Instructions
CENTRIFUGE SST (SERUM GEL TUBES) WITHIN 1-2 HOURS OF COLLECTION. CENTRIFUGE RED TOP VACUTAINERS AND ALIQUOT SERUM WITHIN 1-2 HOURS OF COLLECTION. THE SEPARATION VIAL MUST BE LABELED WITH AT LEAST 2 PATIENT IDENTIFIERS AND THE SAMPLE TYPE.
Reference intervals
APPROPRIATE VALUES ARE PROVIDED ON THE REPORT.
Clinical Utility
MONITORING TREATMENT RESPONSE, DISEASE PROGRESSION & ASSESSING RECURRENCE IN OVARIAN CANCER. LEVELS MAY ALSO BE ELEVATED IN OTHER CANCERS E.G. PANCREATIC, UTERINE CANCERS ETC.
Test Limitations/ Confounders
LEVELS MAY BE ELEVATED IN MULTIPLE BENIGN CONDITIONS E.G. ENDOMETRIOSIS, BENIGN OVARIAN CYSTS, HYPOTHYROIDISM, LIVER CIRRHOSIS, HEART FAILURE, NON-TUMORAL ASSAYS ETC. IMMUNOASSAY INTERFERENCE CAN GIVE RISE TO SPURIOUS RESULTS. SUCH INTERFERENCE CAN ARISE FROM PRESENCE OF HETEROPHILE ANTIBODIES, ANTI-ANIMAL ANTIBODIES, AUTOANTIBODIES, PARAPROTEINS, BIOTIN ETC. RESULTS SHOULD ALWAYS BE CORRELATED WITH CLINICAL FINDINGS.