Test Name

CHROMOSOMAL MICROARRAY, PRENATAL, AMNIOTIC FLUID/ CHORIONIC VILLUS SAMPLING (CVS)

Aliases

PRENATAL SNP MICROARRAY, PRENATAL ARRAY CGH, ARRAY FETO; CHROMOSOMAL ARRAY AMNIOTIC FLUID

Abbreviations

ACGH, CMA, CNV+SNP ARRAY AMNIOTIC FLUID/ CHORIONIC VILLUS SAMPLING (CVS)

Test Classification

INDIVIDUAL

Department

MOLECULAR PATHOLOGY

Sub Department

GENETIC AND HEREDITARY DISORDERS

TAT Category

ELAPSED (CONTINUOUS) TIME

Estimated TAT

12

TAT Units

DAYS

Test Requirements

1st trimester: 20mg chorionic villi biopsy in tissue culture media (or RPMI/ Hank's/ Ringer's lactate/ normal saline to which 2-3 drops of gentamicin have been added). 2nd trimester: 20mL amniotic fluid in sterile falcon tube. Discard first 2ml to avoid contamination with maternal cells. Ensure proper, leak proof capping.

Clinical Utility

Prenatal diagnosis of genomic copy number variations e.g. aneuploidies (e.g. trisomies, turner syndrome, Klinefelter syndrome), mosaicism >20%, microdeletions & microduplications within the assay's resolution. Cannot detect balanced chromosomal rearrangements, single gene disorders, mosaicism <20% etc. Higher risk of uncertain & incidental findings than karyotyping.

Last Review

26th Feb 2026