CHROMOSOMAL MICROARRAY, PRODUCTS OF CONCEPTION (POC)/ STILLBIRTH

Test Name

Aliases

SNP MICROARRAY, ARRAY CGH, ARRAY FETO. CHROMOSOMAL ARRAY PRODUCTS OF CONCEPTION (POC)/ STILLBIRTH

Abbreviations

POC ACGH, POC CMA, CNV+SNP ARRAY PRODUCTS OF CONCEPTION (POC)/ STILLBIRTH

Test Classification

INDIVIDUAL

Department

MOLECULAR PATHOLOGY

Sub Department

GENETIC AND HEREDITARY DISORDERS

TAT Category

ELAPSED (CONTINUOUS) TIME

Estimated TAT

TAT Units

DAYS

Test Requirements

Viable fetal tissue/ products of conception (POCs) in tissue culture media (or RPMI/ Hank's/ Ringer's lactate/ normal saline to which 2-3 drops of gentamicin have been added). First trimester loss: POCs in culture media or normal saline with antibiotics. Second trimester and beyond: dual specimens preferred i.e. 1) placental biopsy from fetal side within 1 inch of the placental insertion site plus 2) fetal tissue (e.g. Muscle biopsy from medial aspect of the thigh or fetal toe). Each biopsy should be at least ~5x5 mm (~size of pencil rubber/ eraser) or larger.

Clinical Utility

Diagnosis of pregnancy losses arising from genomic copy number variations e.g. aneuploidies (e.g. trisomies, Turner syndrome, Klinefelter syndrome), mosaicism >20%, microdeletions & microduplications within the assay's resolution. Cannot detect balanced chromosomal rearrangements, single gene disorders, mosaicism <20% etc. Higher risk of uncertain & incidental findings than karyotyping.

Last Review

26th Feb 2026