Category
SPECIAL CHEMISTRY.
Sub Category
IMMUNE
Synonyms/Aliases
COMPLEMENT COMPONENT 3
Abbreviations
C3
Type
INDIVIDUAL TEST
Results
RESULTS READY/ REPORTED IN 5 WORKING DAYS.
Method
IMMUNOTURBIDIMETRY
Temp
FROZEN PREFERRED. AMBIENT (ROOM) TEMPERATURE NOT ACCEPTABLE.
Setup
BATCHED.
Components Parameters
NOT APPLICABLE
PRE-ANALYTIC CONSIDERATIONS
Test Ordering Instructions
FILL OUT TEST REQUEST FORM FULLY & LEGIBLY. PROVIDE DETAILED CLINICAL HISTORY.
Patient preparation
10-12 HRS. FASTING PREFERRED.
Sample type
SERUM
Container/ preservative
SERUM SEPARATOR TUBE (SST/ GEL) OR PLAIN (RED TOP) VACUTAINER.
Sample volume
AT LEAST 2ML.
Rejection criteria
LABELING ISSUE (UNLABELED/ MISLABELED); MISSING REQUEST FORM; MISMATCH BETWEEN REQUEST FORM & SAMPLE DETAILS; MISSING AGE/ GENDER; WRONG SAMPLE TYPE; INSUFFICIENT SAMPLE.
Other Instructions
CENTRIFUGE SST (SERUM GEL TUBES) WITHIN 1-2 HOURS OF COLLECTION. CENTRIFUGE RED TOP VACUTAINERS AND ALIQUOT SERUM WITHIN 1-2 HOURS OF COLLECTION. THE SEPARATION VIAL MUST BE LABELED WITH AT LEAST 2 PATIENT IDENTIFIERS AND THE SAMPLE TYPE.
Reference intervals
APPROPRIATE VALUES ARE PROVIDED ON THE REPORT.
Clinical Utility
SUSPECTED COMPLEMENT CONSUMPTION (E.G. IN SLE, CRYOGLOBULINEMIA). MONITORING DISEASE ACTIVITY, GLOMERULONEPHRITIS IN SLE. EVALUATION OF RECURRENT UNEXPLAINED BACTERIAL INFECTIONS OR ATYPICAL HEMOLYTIC UREMIC SYNDROME.
Test Limitations/ Confounders
TEMPERATURE SENSITIVE ANALYTE. ANALYTE IS A POSITIVE ACUTE PHASE REACTANT. LEVELS AFFECTED BY COMPLEMENT INHIBITORY DRUGS E.G. ECULIZUMAB.