CSF IgG INDEX – ScanLab Center

Sub Category

FLUID ANALYSIS; INFLAMMATION

Synonyms/Aliases

CSF IgG INDEX PROFILE, SERUM & CEREBROSPINAL FLUID; CSF IMMUNOGLOBULIN G INDEX; IMMUNOGLOBULIN G, CSF INDEX; IMMUNOGLOBULIN G INDEX; IgG SYNTHESIS, CSF.

Abbreviations

-N/A

^Type

PROFILE/ PANEL (BUNDLED TESTS)

^Results

RESULTS READY/ REPORTED 7 WORKING DAYS

^Method

SPECTROPHOTOMETRY FOR SERUM ALBUMIN. NEPHELOMETRY OR IMMUNOTURBIDIMETRY FOR OTHER ANALYTES.

^Temp

REFRIGERATED OR FROZEN.

^Setup

BATCHED.

Components Parameters

IgG (SERUM & CSF), IgG RATIO (CSF IgG/ SERUM IgG), ALBUMIN (SERUM & CSF), ALBUMIN RATIO (CSF ALBUMIN/ SERUM ALBUMIN) & IgG INDEX (CSF/ SERUM IgG RATIO DIVIDED BY CSF/ SERUM ALBUMIN RATIO).

PRE-ANALYTIC CONSIDERATIONS

Test Ordering Instructions

FILL OUT TEST REQUEST FORM FULLY & LEGIBLY.

Patient preparation

NO PREPARATION REQUIRED.

Sample type

TWO SAMPLE TYPES CONCURRENTLY OBTAINED I.E. SERUM AND CSF (OR COLLECTED WITHIN THE SAME DAY).

Container/ preservative

SERUM SEPARATOR TUBE (SST/ GEL) OR PLAIN (RED TOP) VACUTAINER FOR SERUM COLLECTION. STERILE TUBE FOR CSF COLLECTION (IF A SERIES OF CSF TUBES ARE COLLECTED, SUBMIT TUBE 3).

Sample volume

2ML SERUM PLUS 2ML CSF.

Rejection criteria

LABELING ISSUE (UNLABELED/ MISLABELED); MISSING REQUEST FORM; MISMATCH BETWEEN REQUEST FORM & SAMPLE DETAILS; MISSING AGE/ GENDER; WRONG SAMPLE TYPE; INSUFFICIENT SAMPLE.

Other Instructions

NOT APPLICABLE

Reference intervals

INTERPRETIVE DATA IS PROVIDED ON THE REPORT.

Clinical Utility

USED TO CHECK INTEGRITY OF THE BLOOD BRAIN BARRIER (BBB) & FOR INFLAMMATORY DISEASES OF THE CENTRAL NERVOUS SYSTEM E.G. MULTIPLE SCLEROSIS, GBS, LUPUS CEREBRITIS, ENCEPHALITIS, TRANSVERSE MYELITIS, NEUROSYPHILIS WHICH ARE ASSOCIATED WITH INTRATHECAL IGG SYNTHESIS.

Test Limitations/ Confounders

INTRATHECAL IgG SYNTHESIS IS NOT SPECIFIC FOR MULTIPLE SCLEROSIS. CONSIDER TESTING FOR OLIGOCLONAL BANDS IF THERE IS A HIGH INDEX OF SUSPICION.