Category
SPECIAL CHEMISTRY.
Sub Category
DRUGS/ TDM/ TOXICOLOGY
Synonyms/Aliases
CYCLOSPORIN
Abbreviations
C2 (CYCLOSPORIN 2 HOURS POST DOSE), C0 (CYCLOSPORINE TROUGH/ PREDOSE LEVEL)
Type
INDIVIDUAL TEST
Results
RESULTS READY/ REPORTED 7 WORKING DAYS
Method
IMMUNOASSAY
Temp
REFRIGERATED
Setup
BATCHED.
Components Parameters
IgG (SERUM & CSF), IgG RATIO (CSF IgG/ SERUM IgG), ALBUMIN (SERUM & CSF), ALBUMIN RATIO (CSF ALBUMIN/ SERUM ALBUMIN) & IgG INDEX (CSF/ SERUM IgG RATIO DIVIDED BY CSF/ SERUM ALBUMIN RATIO).
PRE-ANALYTIC CONSIDERATIONS
Test Ordering Instructions
FILL OUT TEST REQUEST FORM FULLY & LEGIBLY. DETAILED SPECIFIC HISTORY IS REQUIRED E.G. EXACT INDICATION FOR DRUG MONITORING, DRUG HISTORY (I.E. DOSE, ROUTE OF ADMINISTRATION, DURATION SINCE TREATMENT WAS STARTED OR DOSE ADJUSTED, CONCURRENT MEDICATION), HEIGHT, WEIGHT. MUST SPECIFY WHETHER DRUG COLLECTION SHOULD BE DONE PRE-DOSE (C0) OR TWO HOURS POST DOSE (C2).
Patient preparation
SPECIFIC TIMING APPLIES I.E. TROUGH (PRE-DOSE; C0) OR TWO HOURS POST DOSE (C2) SAMPLE AS SPECIFIED BY THE ORDERING DOCTOR/ CLINICIAN.
Sample type
EDTA WHOLE BLOOD (MOST OF THE DRUG IS BOUND TO ERYTHROCYTES).
Container/ preservative
EDTA (PURPLE TOP) VACUTAINER
Sample volume
AT LEAST 3 ML
Rejection criteria
LABELING ISSUE (UNLABELED/ MISLABELED); MISSING REQUEST FORM; MISMATCH BETWEEN REQUEST FORM & SAMPLE DETAILS; MISSING AGE/ GENDER; WRONG SAMPLE TYPE (E.G. SERUM); INSUFFICIENT SAMPLE; MISSING HISTORY AS EXPOUNDED UNDER TEST ORDERING INSTRUCTIONS.
Other Instructions
NOT APPLICABLE
Reference intervals
INTERPRETIVE DATA IS PROVIDED ON THE REPORT.
Clinical Utility
OPTIMIZE DRUG DOSAGE (TO AVOID SUBTHERAPEUTIC & TOXIC DOSES I.E. ENSURE TARGET THERAPEUTIC RANGE IS ACHIEVED); TO VERIFY COMPLIANCE. CYCLOSPORINE IS AN IMMUNOSUPPRESSANT DRUG USED IN SOLID ORGAN TRANSPLANT RECIPIENTS.
Test Limitations/ Confounders
LEVELS ARE INFLUENCED BY DOSAGE REGIMEN, DRUG INTERACTIONS, INDIVIDUAL'S METABOLIZING CAPACITY, LIVER DYSFUNCTION.