Category
SPECIAL CHEMISTRY.
Sub Category
ENDOCRINE
Synonyms/Aliases
DHEA SULPHATE; DHEA SULFATE
Abbreviations
DHEAS; DHEA-S; DHEA SO4
Type
INDIVIDUAL TEST
Results
RESULTS READY/ REPORTED 7 WORKING DAYS
Method
IMMUNOASSAY
Temp
REFRIGERATED OR FROZEN.
Setup
BATCHED.
Components Parameters
IgG (SERUM & CSF), IgG RATIO (CSF IgG/ SERUM IgG), ALBUMIN (SERUM & CSF), ALBUMIN RATIO (CSF ALBUMIN/ SERUM ALBUMIN) & IgG INDEX (CSF/ SERUM IgG RATIO DIVIDED BY CSF/ SERUM ALBUMIN RATIO).
PRE-ANALYTIC CONSIDERATIONS
Test Ordering Instructions
FILL OUT TEST REQUEST FORM FULLY & LEGIBLY.
Patient preparation
SPECIFIC TIMING APPLIES I.E. TROUGH (PRE-DOSE; C0) OR TWO HOURS POST DOSE (C2) SAMPLE AS SPECIFIED BY THE ORDERING DOCTOR/ CLINICIAN.
Sample type
SERUM
Container/ preservative
SERUM SEPARATOR TUBE (SST/ GEL) OR PLAIN (RED TOP) VACUTAINER.
Sample volume
AT LEAST 2 ML
Rejection criteria
LABELING ISSUE (UNLABELED/ MISLABELED); MISSING REQUEST FORM; MISMATCH BETWEEN REQUEST FORM & SAMPLE DETAILS; MISSING AGE/ GENDER; WRONG SAMPLE TYPE; INSUFFICIENT SAMPLE.
Other Instructions
CENTRIFUGE SST (SERUM GEL TUBES) WITHIN 1-2 HOURS OF COLLECTION. CENTRIFUGE RED TOP VACUTAINERS AND ALIQUOT SERUM WITHIN 1-2 HOURS OF COLLECTION. THE SEPARATION VIAL MUST BE LABELED WITH AT LEAST 2 PATIENT IDENTIFIERS AND THE SAMPLE TYPE.
Reference intervals
AGE, GENDER & TANNER STAGE DEPENDENT.
Clinical Utility
DHEAS IS THE SULPHATED FORM OF DHEA WHICH IS AN ANDROGEN PRIMARILY PRODUCED IN THE ADRENAL CORTEX. ALONG WITH OTHER SEX STEROIDS, IT IS USEFUL IN EVALUATING HIRSUTISM & VIRILIZATION IN WOMEN, SUSPECTED TUMORS OF THE ADRENAL CORTEX, PRECOCIOUS PUBERTY IN BOYS & AS AN ADJUNCT IN SUSPECTED CONGENITAL ADRENAL HYPERPLASIA (CAH).
Test Limitations/ Confounders
IMMUNOASSAY INTERFERENCE CAN GIVE RISE TO SPURIOUS RESULTS. SUCH INTERFERENCE CAN ARISE FROM PRESENCE OF HETEROPHILE ANTIBODIES, ANTI-ANIMAL ANTIBODIES, AUTOANTIBODIES, PARAPROTEINS, BIOTIN ETC. RESULTS SHOULD ALWAYS BE CORRELATED WITH CLINICAL FINDINGS.