Test Name
ER, PR, HER2 IHC PANEL
Aliases
BREAST IHC PANEL, BREAST CARCINOMA IHC PANEL, BREAST PROGNOSTIC/PREDICTIVE IHC PANEL
Abbreviations
-
Test Classification
INDIVIDUAL
Department
ANATOMIC PATHOLOGY
Sub Department
HISTOLOGY
TAT Category
ELAPSED (CONTINUOUS) TIME
Estimated TAT
14
TAT Units
DAYS
Test Requirements
Provide clinical history, imaging findings, and prior therapy.
Acceptable specimens:
1. Fresh breast tissue in 10% neutral buffered formalin (NBF); place in fixative immediately after excision
OR
2. FFPE blocks
OR
3. Unstained positively charged slides (3–5 µm).
Fixation requirements: 6–72 hours in 10% NBF; avoid over-fixation or under-fixation.
Tissue quality: Representative tumor tissue with minimal crush or thermal artifact.
Clinical Utility
Confirms malignancy and subtype.
Determines hormone-receptor status to guide endocrine therapy.
Determines HER2 status for anti-HER2 therapy eligibility.
Forms the basis of molecular surrogate classification (e.g., Luminal vs HER2-enriched vs Basal-like).
Last Review
26th Feb 2026