Category
SPECIAL CHEMISTRY.
Sub Category
ANEMIA & NUTRITION
Synonyms/Aliases
HOMOCYSTINE, SERUM
Abbreviations
- N/A
Type
INDIVIDUAL TEST
Results
RESULTS READY/ REPORTED IN 7 WORKING DAYS
Method
IMMUNOASSAY.
Temp
REFRIGERATED
Setup
BATCHED.
Components Parameters
0 MIN (BASAL) THEN 30MIN, 60MIN, 90MIN, AND 120MIN GROWTH HORMONE AFTER 75G ORAL GLUCOSE LOAD
PRE-ANALYTIC CONSIDERATIONS
Test Ordering Instructions
FILL OUT TEST REQUEST FORM FULLY & LEGIBLY.
Patient preparation
FASTING SPECIMEN IS PREFERRED.
Sample type
SERUM
Container/ preservative
SERUM SEPARATOR TUBE (SST/ GEL) OR PLAIN (RED TOP) VACUTAINER.
Sample volume
AT LEAST 2ML
Rejection criteria
LABELING ISSUE (UNLABELED/ MISLABELED); MISSING REQUEST FORM; MISMATCH BETWEEN REQUEST FORM & SAMPLE DETAILS; MISSING AGE/ GENDER; WRONG SAMPLE TYPE; INSUFFICIENT SAMPLE.
Other Instructions
CENTRIFUGE SST (SERUM GEL TUBES) WITHIN 1-2 HOURS OF COLLECTION. CENTRIFUGE RED TOP VACUTAINERS AND ALIQUOT SERUM WITHIN 1-2 HOURS OF COLLECTION. THE SEPARATION VIAL MUST BE LABELED WITH AT LEAST 2 PATIENT IDENTIFIERS AND THE SAMPLE TYPE.
Reference intervals
AGE & GENDER APPROPRIATE VALUES ARE PROVIDED ON THE REPORT.
Clinical Utility
DIAGNOSE HYPERHOMOCYSTEINEMIA DUE TO ACQUIRED CAUSES (VITAMIN B6, B9, B12 OR FOLIC ACID DEFICIENCY, HYPOTHYROIDISM, RENAL INSUFFICIENCY, SOME DRUGS) OR INHERITED CAUSES (HOMOCYSTINURIA, MTHRF C677T MUTATION ETC.). VITAMIN B12 AND FOLATE CAN BE CONSIDERED AS FOLLOW UP TESTS TO ELEVATED HOMOCYSTEINE RESULTS IF NOT ALREADY PERFORMED. HYPERHOMOCYSTEINEMIA CAN INCREASE THROMBOTIC RISK.
Test Limitations/ Confounders
IMMUNOASSAY INTERFERENCE CAN GIVE RISE TO SPURIOUS RESULTS. SUCH INTERFERENCE CAN ARISE FROM PRESENCE OF HETEROPHILE ANTIBODIES, ANTI-ANIMAL ANTIBODIES, AUTOANTIBODIES, PARAPROTEINS, BIOTIN ETC. RESULTS SHOULD ALWAYS BE CORRELATED WITH CLINICAL FINDINGS.