Test Name
HUMAN EPIDIDYMIS PROTEIN 4 (HE4)
Aliases
HUMAN EPIDIDYMAL SECRETORY PROTEIN E4, EPIDIDYMAL SECRETORY PROTEIN E4
Abbreviations
-
Test Classification
INDIVIDUAL
Department
SPECIAL CHEMISTRY
Sub Department
-
TAT Category
ELAPSED (CONTINUOUS) TIME
Estimated TAT
7
TAT Units
DAYS
Test Requirements
Sample Type: Serum.
Fasting: Not required.
Storage: Store refrigerated or frozen. Stable at 2–8°C for 2-4 days; for longer storage, freeze at –20°C or below.
Clinical Utility
Primary use: Monitoring and risk assessment of epithelial ovarian cancer. May be tested in conjunction with CA125. HE4 levels are less likely to be elevated in benign gynecological conditions compared to CA-125. Not diagnostic alone; elevated HE4 can occur in endometriosis, kidney disease, or lung cancer.
Secondary use: May aid in distinguishing benign vs. malignant pelvic masses.
Last Review
26th Feb 2026