K-RAS MUTATION, TISSUE BLOCK

Test Name

Aliases

KRAS MUTATION, TISSUE BLOCK

Abbreviations

Test Classification

GROUPED TEST

Department

MOLECULAR PATHOLOGY

Sub Department

ONCOLOGY

TAT Category

ELAPSED (CONTINUOUS) TIME

Estimated TAT

168

TAT Units

HOURS

Test Requirements

SAMPLE TYPE: Tumor positive formalin-fixed, paraffin-embedded (FFPE) block with adequate residual tissue. CONTAINER/ PRESERVATIVE: Formalin fixed, paraffin embedded blocks [preferred]. Alternatively, 5 microns unstained sections on positively-charged slides (≥four slides) & 1 matching H&E slide.

Clinical Utility

Detects presence or absence of KRAS codon 12/13 (exon 2) mutations. A predictive/ theranostic marker for colorectal & non-small cell lung cancer. Patients with positive results indicate resistance to anti-EGFR therapy e.g. Cetuximab (Erbitux), Panitumumab (Vectibix).

Last Review

26th Feb 2026