LUPUS ANTICOAGULANT (LA) PANEL

SubCategory

Thrombosis/ Thrombosis risk assessment

Abbreviations

LAC, dRVVT, RVVT

Synonyms/Aliases

Lupus Anticoagulant profile, APTT mixing studies, dilute russel viper venom time (DRVVT)

^Test

profile/ panel (bundled tests)

^Results

results ready aftre 7-10 working Days

^Method

Mixed E.g. Time To Clotting (APTT); Mixing Studies, Calculation Of Ratios

^Temp

Transportation temperature need to be Frozen

^Setup

Setup is Conducted Once a week

Pre-analytic Considerations

Component Parameters

APTT, Dilute Russel Viper Venom Time (DRVVT), Mixing Studies

Sample Requirements

Citrated whole blood/ plasma

Test Ordering Instructions

fill out test request form fully & legibly.

Container / Presavative

citrate (light blue top) vacutainer during sample collection.

Test Considerations

fill out test request form fully & legibly.

Patient Preparations

fasting preferred to avoid lipemia.

Sample Types

citrated platelet poor plasma (frozen)

Sample Volume

during sample collection, fill up to the mark on the tube (do not "add up" samples collected in other tubes to reach the required volume). submit 4ml platelet poor (double centrifuged) frozen citrated plasma in a separation vial. the aliquot label should identify the sample type as citrated plasma.

Rejection Criteria

labeling issue (unlabeled/ mislabeled); missing request form; mismatch between request form & sample details; missing age/ gender; wrong sample type; insufficient sample; hemolyzed samples; clotted samples; incorrect temperature handling.

Reference intervals

Appropriate values are provided on the report

Clinical utility

Rule out LUPUS anticoagulant; evaluation of thrombotic states.

Test Limitations /Confounders

Anticoagulants may result to false positive results. this is a temperature sensitive analyte; frozen handling required.

Other Instructions

To prepare platelet poor plasma, double centrifuge sample immediately after collection i.e. centrifuge, transfer plasma, centrifuge plasma a second time & transfer the supernatant which should now be platelet poor. freeze immediately.