METANEPHRINES, 24 HR URINE

Sub Category

TUMOR MARKER.

Synonyms/Aliases

FRACTIONATED METANEPHRINES, 24 HR URINE.

Abbreviations

N/A.

^Type

PROFILE/ PANEL (BUNDLED TESTS).

^{7 Days}

RESULTS READY/ REPORTED IN 7 WORKING DAYS.

^Method

CHROMATOGRAPHY.

^Temp

FROZEN (PREFERRED) OR REFRIGERATED.

^Setup

BATCHED.

Components Parameters

NORMETANEPHRINE & METANEPHRINE.

PRE-ANALYTIC CONSIDERATIONS

Test Ordering Instructions

FILL OUT TEST REQUEST FORM FULLY & LEGIBLY. TOTAL VOLUME OF COLLECTED 24 HOUR URINE IS REQUIRED. PROVIDE CLINICAL HISTORY & PATIENT'S CURRENT DRUG HISTORY. DISCONTINUE ANTIHYPERTENSIVE DRUGS IF FEASIBLE (MULTIPLE DRUGS CAN INCREASE OR DECREASE METANEPHRINE LEVELS; CONSULT PATHOLOGIST IF IN DOUBT).

Patient preparation

ACCURATELY TIMED 24 HOUR COLLECTION (E.G. 6A.M., DAY 1 TO 6A.M., DAY 2) IS CRUCIAL FOR RESULT ACCURACY. COLLECT URINE IN A CLEAN WIDE MOUTH CONTAINER & TRANSFER ENTIRE COLLECTION INTO THE CONTAINER THAT WAS PROVIDED BY THE LAB. REFRIGERATE DURING COLLECTION. KEEP OUT OF REACH OF CHILDREN (CONTAINS CORROSIVE SUBSTANCES). DO NOT CONSUME FOODS RICH IN SEROTONIN (E.G. BANANAS, PINEAPPLE, CEREALS, POTATOES, COFFEE, TEA, CHOCOLATE, VANILLA ETC.) FOR 72 HOURS PRIOR TO SAMPLE COLLECTION. AVOID STRENUOUS EXERCISE.

Sample type

24 HOUR URINE.

Container/ preservative

CLEAN CONTAINER WITH 10ML OF 6N HCL PRESERVATIVE ISSUED BY THE LAB.

Sample volume

10ML ALIQUOT OF 24 HOUR URINE. ORIGINAL (TOTAL) VOLUME IN ML MUST BE SPECIFIED ON THE REQUEST FORM.

Rejection criteria

LABELING ISSUE (UNLABELED/ MISLABELED); MISSING REQUEST FORM; MISMATCH BETWEEN REQUEST FORM & SAMPLE DETAILS; MISSING AGE/ GENDER; WRONG SAMPLE TYPE; INSUFFICIENT SAMPLE; 24 HOUR URINE VOLUME NOT PROVIDED.

Other Instructions

N/A.

Reference intervals

INTERPRETIVE DATA IS PROVIDED ON THE REPORT.

Clinical Utility

METANEPHRINES ARE METABOLITES OF CATECHOLAMINES. EVALUATION OF HYPERTENSION AND CATECHOLAMINE SECRETING TUMOURS LIKE PHEOCHROMOCYTOMA, NEUROBLASTOMA AND PARAGANGLIOMA.

Test Limitations/ Confounders

DIETARY & DRUG INTERFERENCE CAN OCCUR. RESULTS SHOULD ALWAYS BE CORRELATED WITH CLINICAL FINDINGS & RESULTS OF OTHER DIAGNOSTIC WORK-UP E.G. IMAGING, TISSUE BIOPSY FINDINGS.