Category
Anatomic Pathology
Sub Category
Surgical/ Histopathology
Synonyms/Aliases
Mismatch Repair (MMR) Protein, IHC
Abbreviations
MMR, IHC
Type
profile/ panel (bundled tests)
Result
Results will be ready after 14 days
Method
immunostain & reporting
Temp
Transported temprature be at room temperature; refrigerated is also acceptable.
Setup
Mon-Fri All working Days
Components Parameters
MSH2, MSH6, MLH1, PMS2mismatch repair proteins
PRE-ANALYTIC CONSIDERATIONS
:
Test Ordering Instructions
Fill out test request form fully & legibly. provide your contact information & complete history. h&e report required.
Patient preparation
N/A
Sample type
Formalin fixed paraffin embedded blocks/ stained slides only
Container/ preservative
Formalin fixed paraffin embedded blocks/ stained slides only
Sample volume
Residual tissue must be available on the block
Rejection criteria
Labeling issue (unlabeled/ mislabeled); missing request form; mismatch between request form & sample details; wrong sample type or fixative; insufficient/ depleted sample.
Other Instructions
N/A
Reference intervals
N/A
Clinical Utility
Evaluation/ Screening Of Lynch Syndrome Or Hereditary Non-polyposis Colorectal Cancer (HNPCC).
Test Limitations/ Confounders
Positive Results Require Follow Up Microsatellite Instability (Msi) Testing For Quantification In Order To Distinguish Between High & LowMSI. High MSI Is Associated With Poorer Prognosis.