MYASTHENIA GRAVIS PROFILE – ScanLab Center

Sub Category

AUTOIMMUNE.

Synonyms/Aliases

MYASTHENIA GRAVIS PANEL.

Abbreviations

N/A

^Type

PROFILE/ PANEL (BUNDLED TESTS).

^{7 DAYS}

7 WORKING DAYS

^Method

RADIOIMMUNOASSAY.

^Temp

REFRIGERATED OR FROZEN.

^Setup

BATCHED.

Components Parameters

1) MUSCLE SPECIFIC KINASE (MuSK) ANTIBODY, 2) ANTI SKELETAL (STRIATED) MUSCLE ANTIBODY (ASKA), 3) ACETYLCHOLINE RECEPTOR (AChR) ANTIBODY.

PRE-ANALYTIC CONSIDERATIONS

Test Ordering Instructions

FILL OUT TEST REQUEST FORM FULLY & LEGIBLY.

Patient preparation

N/A.

Sample type

SERUM.

Container/ preservative

SERUM SEPARATOR TUBE (SST/ GEL) OR PLAIN (RED TOP) VACUTAINER.

Sample volume

AT LEAST 5ML.

Rejection criteria

LABELING ISSUE (UNLABELED/ MISLABELED); MISSING REQUEST FORM; MISMATCH BETWEEN REQUEST FORM & SAMPLE DETAILS; MISSING AGE/ GENDER; WRONG SAMPLE TYPE; INSUFFICIENT SAMPLE.

Other Instructions

CENTRIFUGE SST (SERUM GEL TUBES) WITHIN 1-2 HOURS OF COLLECTION. CENTRIFUGE RED TOP VACUTAINERS AND ALIQUOT SERUM WITHIN 1-2 HOURS OF COLLECTION. THE SEPARATION VIAL MUST BE LABELED WITH AT LEAST 2 PATIENT IDENTIFIERS AND THE SAMPLE TYPE.

Reference intervals

NEGATIVE.

Clinical Utility

TO DIAGNOSE GENERALIZED AND OCULAR MYASTHENIA GRAVIS. TO DISTINGUISH MYASTHENIA GRAVIS FROM OTHER CONDITIONS WITH SIMILAR SYMPTOMS.

Test Limitations/ Confounders

10-15% OF PATIENTS WITH GENERALIZED MYASTHENIA GRAVIS AND 25-50% OF PATIENTS WITH OCULAR MYASTHENIA ARE SERONEGATIVE FOR ACHR BUT MAY BE SEROPOSITIVE FOR OTHER MARKERS E.G. MuSK.