Category
ROUTINE CHEMISTRY.
Sub Category
METABOLIC.
Synonyms/Aliases
CROSSLINKED N-TELOPEPTIDE OF TYPE 1 COLLAGEN; N-TELOPEPTIDE, URINE; NTX-TELOPEPTIDE; COLLAGEN CROSSLINKS.
Abbreviations
NTx.
Type
INDIVIDUAL TEST.
10 Days
RESULTS READY/ REPORTED IN 10 WORKING DAYS.
Method
IMMUNOASSAY.
Temp
AMBIENT, 24-72 HOURS; REFRIGERATED, 2-8ºC, 7 DAYS; FROZEN, 30 DAYS.
Setup
BATCHED.
Components Parameters
NOT APPLICABLE.
PRE-ANALYTIC CONSIDERATIONS
Test Ordering Instructions
FILL OUT TEST REQUEST FORM FULLY & LEGIBLY. TOTAL 24 HOUR URINE VOLUME (ML) IS REQUIRED.
Patient preparation
ACCURATELY TIMED 24 HOUR COLLECTION (E.G. 6A.M., DAY 1 TO 6A.M., DAY 2) IS CRUCIAL FOR RESULT ACCURACY. COLLECT URINE IN A CLEAN WIDE MOUTH CONTAINER & TRANSFER ENTIRE COLLECTION INTO THE CONTAINER THAT WAS PROVIDED BY THE LAB. REFRIGERATE DURING COLLECTION.
Sample type
24 HOUR URINE.
Container/ preservative
CLEAN, LEAK PROOF CONTAINER, NO PRESERVATIVE. REFRIGERATE DURING COLLECTION.
Sample volume
10ML ALIQUOT OF 24 HOUR URINE WITHOUT PRESERVATIVE. ORIGINAL (TOTAL) VOLUME IN ML MUST BE SPECIFIED ON THE REQUEST FORM.
Rejection criteria
LABELING ISSUE (UNLABELED/ MISLABELED); MISSING REQUEST FORM; MISMATCH BETWEEN REQUEST FORM & SAMPLE DETAILS; MISSING AGE/ GENDER; WRONG SAMPLE TYPE; INSUFFICIENT SAMPLE; 24 HOUR URINE VOLUME NOT PROVIDED.
Other Instructions
ACCURACY OF RESULTS IS DEPENDENT ON COMPLETE COLLECTION & ACCURATE TIMING OF THE 24 HOUR URINE SAMPLE.
Reference intervals
AGE AND GENDER APPROPRIATE VALUES PROVIDED WITH REPORT.
Clinical Utility
BONE RESORPTION MARKER FOR DIAGNOSIS OF METABOLIC BONE DISORDERS OR DISORDERS ASSOCIATED WITH INCREASED BONE TURNOVER (E.G. OSTEOPENIA, HIGH TURNOVER OSTEOPOROSIS, PAGET DISEASE, METASTATIC BONE DISEASE ETC.). MONITORING RESPONSE TO ANTI-RESORPTIVE THERAPY.
Test Limitations/ Confounders
TO AVOID BIOTIN INTERFERENCE, AVOID BIOTIN CONTAINING MULTIVITAMINS & SUPPLEMENTS FOR AT LEAST 24 HOURS PRIOR TO COLLECTION.