Category

SPECIAL CHEMISTRY.

Sub Category

DRUGS/ TDM/ TOXICOLOGY.

Synonyms/Aliases

ASTAGRAF XL, ENVARSUS XR, PROGRAF, HECORIA.

Abbreviations

N/A.

Type

INDIVIDUAL TEST.

5 DAYS

RESULTS READY/ REPORTED IN 5 WORKING DAYS.

Method

IMMUNOASSAY.

Temp

REFRIGERATED.

Setup

BATCHED.

Components Parameters

N/A.

PRE-ANALYTIC CONSIDERATIONS

Test Ordering Instructions

FILL OUT TEST REQUEST FORM FULLY & LEGIBLY. DETAILED SPECIFIC HISTORY IS REQUIRED E.G. EXACT INDICATION FOR DRUG MONITORING, DRUG HISTORY (I.E. DOSE, ROUTE OF ADMINISTRATION, DURATION SINCE TREATMENT WAS STARTED OR DOSE ADJUSTED, CONCURRENT MEDICATION), HEIGHT, WEIGHT.

Patient preparation

SPECIFIC TIMING APPLIES I.E. COLLECT TROUGH (PRE-DOSE) SAMPLE.

Sample type

EDTA WHOLE BLOOD (MOST OF THE DRUG IS BOUND TO ERYTHROCYTES).

Container/ preservative

EDTA (PURPLE TOP) VACUTAINER.

Sample volume

AT LEAST 3ML EDTA WHOLE BLOOD.

Rejection criteria

LABELING ISSUE (UNLABELED/ MISLABELED); MISSING REQUEST FORM; MISMATCH BETWEEN REQUEST FORM & SAMPLE DETAILS; MISSING AGE/ GENDER; WRONG SAMPLE TYPE; INSUFFICIENT SAMPLE; MISSING HISTORY AS EXPOUNDED UNDER TEST ORDERING INSTRUCTIONS.

Other Instructions

NOT APPLICABLE.

Reference intervals

INTERPRETIVE DATA IS PROVIDED ON THE REPORT.

Clinical Utility

OPTIMIZE DRUG DOSAGE (TO AVOID SUBTHERAPEUTIC & TOXIC DOSES I.E. ENSURE TARGET THERAPEUTIC RANGE IS ACHIEVED); TO VERIFY COMPLIANCE. TACROLIMUS IS AN IMMUNOSUPPRESSANT DRUG USED IN SOLID ORGAN TRANSPLANT RECIPIENTS.

Test Limitations/ Confounders

LEVELS ARE INFLUENCED BY DOSAGE REGIMEN, DRUG INTERACTIONS, INDIVIDUAL'S METABOLIZING CAPACITY, LIVER DYSFUNCTION.