Category
SPECIAL CHEMISTRY.
Sub Category
CARDIAC ASSESSMENT.
Synonyms/Aliases
TROPONIN I, HIGH SENSITIVITY; CARDIAC TROPONIN I; HIGHLY SENSITIVE TROPONIN I.
Abbreviations
cTnI.
Type
INDIVIDUAL TEST.
2 HOURS
RESULTS READY/ REPORTED IN 2 HOURS.
Method
IMMUNOASSAY
Temp
REFRIGERATED.
Setup
DAILY.
Components Parameters
NOT APPLICABLE.
PRE-ANALYTIC CONSIDERATIONS
Test Ordering Instructions
FILL OUT TEST REQUEST FORM FULLY & LEGIBLY.
Patient preparation
NOT APPLICABLE.
Sample type
SERUM.
Container/ preservative
SERUM SEPARATOR TUBE (SST/ GEL) OR PLAIN (RED TOP) VACUTAINER.
Sample volume
AT LEAST 2 ML.
Rejection criteria
LABELING ISSUE (UNLABELED/ MISLABELED); MISSING REQUEST FORM; MISMATCH BETWEEN REQUEST FORM & SAMPLE DETAILS; MISSING AGE/ GENDER; WRONG SAMPLE TYPE; INSUFFICIENT SAMPLE.
Other Instructions
CENTRIFUGE SST (SERUM GEL TUBES) WITHIN 1-2 HOURS OF COLLECTION. CENTRIFUGE RED TOP VACUTAINERS AND ALIQUOT SERUM WITHIN 1-2 HOURS OF COLLECTION. THE SEPARATION VIAL MUST BE LABELED WITH AT LEAST 2 PATIENT IDENTIFIERS AND THE SAMPLE TYPE.
Reference intervals
AGE, GENDER & METHOD APPROPRIATE VALUES ARE PROVIDED ON THE REPORT.
Clinical Utility
EVALUATE SUSPECTED MYOCARDIAL INFARCTION (HEART ATTACK)/ ACUTE CORONARY SYNDROME. FOR THIS INDICATION, TROPONIN IS CONSIDERED SUPERIOR TO CARDIAC ENZYMES (CK-MB, LDH, AST).
Test Limitations/ Confounders
DETECTS MYOCARDIAL DAMAGE THEREFORE ELEVATED LEVELS MAY OCCUR DUE TO CONDITIONS OTHER THAN MYOCARDIAL INFARCTION E.G. MYOCARDITIS, CONGESTIVE HEART FAILURE, UNSTABLE ANGINA ETC. IT MAY ALSO BE ELEVATED DUE TO NON-CARDIAC CAUSES LIKE PULMONARY EMBOLISM. IMMUNOASSAY INTERFERENCE CAN GIVE RISE TO SPURIOUS RESULTS. SUCH INTERFERENCE CAN ARISE FROM PRESENCE OF HETEROPHILE ANTIBODIES, ANTI-ANIMAL ANTIBODIES, AUTOANTIBODIES, PARAPROTEINS, BIOTIN ETC. RESULTS SHOULD ALWAYS BE CORRELATED WITH CLINICAL, ECG & OTHER FINDINGS.