Special chemistry – Page 2

11 Jun

FOLATE

June 11, 2023June 11, 2023vincentochiengde

Category

SPECIAL CHEMISTRY.

Sub Category

ANEMIA & NUTRITION

Synonyms/Aliases

FOLIC ACID; VITAMIN B9.

Abbreviations

^Type

INDIVIDUAL TEST

^Results

RESULTS READY/ REPORTED IN 3 WORKING DAYS.

^Method

IMMUNOASSAY.

^Temp

REFRIGERATED

^Setup

BATCHED.

Components Parameters

NOT APPLICABLE

PRE-ANALYTIC CONSIDERATIONS

Test Ordering Instructions

FILL OUT TEST REQUEST FORM FULLY & LEGIBLY.

Patient preparation

NO PREPARATION REQUIRED

Sample type

SERUM

Container/ preservative

SERUM SEPARATOR TUBE (SST/ GEL) OR PLAIN (RED TOP) VACUTAINER.

Sample volume

AT LEAST 2ML

Rejection criteria

LABELING ISSUE (UNLABELED/ MISLABELED); MISSING REQUEST FORM; MISMATCH BETWEEN REQUEST FORM & SAMPLE DETAILS; MISSING AGE/ GENDER; WRONG SAMPLE TYPE; INSUFFICIENT SAMPLE.

Other Instructions

Reference intervals

INTERPRETIVE DATA IS PROVIDED ON THE REPORT.

Clinical Utility

DIAGNOSE CAUSE OF ANEMIA OR NEUROPATHY.

Test Limitations/ Confounders

RECENT USE OF FOLIC ACID ANTAGONISTS E.G METHOTREXATE AFFECTS RESULTS. IMMUNOASSAY INTERFERENCE CAN GIVE RISE TO SPURIOUS RESULTS. SUCH INTERFERENCE CAN ARISE FROM PRESENCE OF HETEROPHILE ANTIBODIES, ANTI-ANIMAL ANTIBODIES, AUTOANTIBODIES, PARAPROTEINS, BIOTIN ETC. RESULTS SHOULD ALWAYS BE CORRELATED WITH CLINICAL FINDINGS.

11 Jun

FERRITIN

June 11, 2023June 11, 2023vincentochiengde

Category

SPECIAL CHEMISTRY.

Sub Category

ANEMIA & NUTRITION

Synonyms/Aliases

N/A

Abbreviations

N/A

^Type

INDIVIDUAL TEST

^Results

RESULTS READY/ REPORTED2-4 HOURS.

^Method

IMMUNOASSAY.

^Temp

REFRIGERATED

^Setup

DAILY

Components Parameters

NOT APPLICABLE

PRE-ANALYTIC CONSIDERATIONS

Test Ordering Instructions

FILL OUT TEST REQUEST FORM FULLY & LEGIBLY.

Patient preparation

NO PREPARATION REQUIRED

Sample type

SERUM. HEPARIN PLASMA IS AN ACCEPTABLE ALTERNATE SPECIMEN.

Container/ preservative

SERUM SEPARATOR TUBE (SST/ GEL) OR PLAIN (RED TOP) VACUTAINER.

Sample volume

AT LEAST 2 ML

Rejection criteria

LABELING ISSUE (UNLABELED/ MISLABELED); MISSING REQUEST FORM; MISMATCH BETWEEN REQUEST FORM & SAMPLE DETAILS; MISSING AGE/ GENDER; WRONG SAMPLE TYPE; INSUFFICIENT SAMPLE.

Other Instructions

Reference intervals

AGE & GENDER APPROPRIATE VALUES ARE PROVIDED ON THE REPORT.

Clinical Utility

DIAGNOSING IRON DEFICIENCY ANEMIA (HYPOFERRITINEMIA) AND IRON OVERLOAD CONDITIONS (HYPERFERRITINEMIA).

Test Limitations/ Confounders

FERRITIN IS A POSITIVE ACUTE PHASE REACTANT THEREFORE CONCURRENT INFLAMMATION IS A CONFOUNDING FACTOR.

11 Jun

ESTRADIOL

June 11, 2023June 11, 2023vincentochiengde

Category

SPECIAL CHEMISTRY.

Sub Category

ENDOCRINE

Synonyms/Aliases

OESTRADIOL; 17 BETA ESTRADIOL; OESTROGEN; ESTROGEN

Abbreviations

^Type

INDIVIDUAL TEST

^Results

RESULTS READY/ REPORTED 24-48 HOURS

^Method

IMMUNOASSAY.

^Temp

AMBIENT, REFRIGERATED (PREFERRED) OR FROZEN.

^Setup

DAILY

Components Parameters

NOT APPLICABLE

PRE-ANALYTIC CONSIDERATIONS

Test Ordering Instructions

FILL OUT TEST REQUEST FORM FULLY & LEGIBLY.

Patient preparation

NO PREPARATION REQUIRED

Sample type

SERUM. HEPARIN PLASMA IS AN ACCEPTABLE ALTERNATE SPECIMEN.

Container/ preservative

SERUM SEPARATOR TUBE (SST/ GEL) OR PLAIN (RED TOP) VACUTAINER.

Sample volume

AT LEAST 2 ML

Rejection criteria

LABELING ISSUE (UNLABELED/ MISLABELED); MISSING REQUEST FORM; MISMATCH BETWEEN REQUEST FORM & SAMPLE DETAILS; MISSING AGE/ GENDER; WRONG SAMPLE TYPE; INSUFFICIENT SAMPLE.

Other Instructions

Reference intervals

AGE, GENDER, MENSTRUAL PHASE (FOLLICULAR PHASE VS. MID CYCLE PEAK VS. LUTEAL PHASE), POST MENOPAUSAL REFERENCE INTERVALS (AS APPROPRIATE) ARE PROVIDED ON THE REPORT.

Clinical Utility

ASSESSING OVARIAN FUNCTION, MONITOR FOLLICULAR DEVELOPMENT IN ASSISTED REPRODUCTION/ IVF PROTOCOLS, PRECOCIOUS PUBERTY, MENSTRUAL CYCLE (PERI-OVULATORY/ MID-CYCLE), GYNECOMASTIA.

Test Limitations/ Confounders

IMMUNOASSAY INTERFERENCE CAN GIVE RISE TO SPURIOUS RESULTS. SUCH INTERFERENCE CAN ARISE FROM PRESENCE OF HETEROPHILE ANTIBODIES, ANTI-ANIMAL ANTIBODIES, AUTOANTIBODIES, PARAPROTEINS, BIOTIN ETC. RESULTS SHOULD ALWAYS BE CORRELATED WITH CLINICAL FINDINGS.

11 Jun

ERYTHROPOIETIN

June 11, 2023June 11, 2023vincentochiengde

Category

SPECIAL CHEMISTRY.

Sub Category

ANEMIA & NUTRITION; ENDOCRINE

Synonyms/Aliases

HEMOPOIETIN; EPOGEN

Abbreviations

EPO

^Type

INDIVIDUAL TEST

^Results

RESULTS READY/ REPORTED 5 WORKING DAYS

^Method

IMMUNOASSAY.

^Temp

REFRIGERATED

^Setup

BATCHED.

Components Parameters

NOT APPLICABLE

PRE-ANALYTIC CONSIDERATIONS

Test Ordering Instructions

FILL OUT TEST REQUEST FORM FULLY & LEGIBLY. MULTI-SAMPLING WILL BE DONE. SPECIFY EXACT DEXAMETHASONE SUPPRESSION TEST (VARIATIONS CAN OCCUR E.G. LOW DOSE 48-HOUR DST; HIGH DOSE 48-HOUR DST; SIMILAR TESTS MAY ALSO BE PERFORMED FOR A DIFFERENT ANALYTE I.E. ACTH). PROVIDE CLINICAL HISTORY. PRESCRIBE DEXAMETHASONE I.E. 1 MG FOR ADULTS; 0.3MG/M2 FOR CHILDREN.

Patient preparation

NO PREPARATION REQUIRED

Sample type

SERUM

Container/ preservative

SERUM SEPARATOR TUBE (SST/ GEL) OR PLAIN (RED TOP) VACUTAINER.

Sample volume

AT LEAST 2 ML

Rejection criteria

LABELING ISSUE (UNLABELED/ MISLABELED); MISSING REQUEST FORM; MISMATCH BETWEEN REQUEST FORM & SAMPLE DETAILS; MISSING AGE/ GENDER; WRONG SAMPLE TYPE; INSUFFICIENT SAMPLE.

Other Instructions

Reference intervals

AGE & GENDER APPROPRIATE VALUES ARE PROVIDED ON THE REPORT.

Clinical Utility

AN ADJUNCT TO HELP DIAGNOSE THE CAUSE OF ANEMIA; AN ADUNCT TO HELP DIFFERENTIATE BETWEEN PRIMARY VS SECONDARY POLYCYTHEMIA OR ERYTHROCYTOSIS.

Test Limitations/ Confounders

EXHIBITS DIURNAL VARIATION. LEVELS INFLUENCED BY ALTITUDE.

11 Jun

DIHYDROTESTOSTERONE

June 11, 2023June 11, 2023vincentochiengde

Category

SPECIAL CHEMISTRY.

Sub Category

ENDOCRINE

Synonyms/Aliases

5-ALPHA DIHYDROTESTOSTERONE

Abbreviations

DHT

^Type

PROFILE/ PANEL (BUNDLED TESTS)

^Results

RESULTS READY/ REPORTED 7 WORKING DAYS

^Method

IMMUNOASSAY.

^Temp

AMBIENT, REFRIGERATED (PREFERRED) OR FROZEN.

^Setup

BATCHED.

Components Parameters

BASAL (PRE-DEXAMETHASONE) 8AM & POST DEXAMETHASONE 8AM CORTISOL LEVELS.

PRE-ANALYTIC CONSIDERATIONS

Test Ordering Instructions

Patient preparation

NO PREPARATION REQUIRED

Sample type

SERUM

Container/ preservative

SERUM SEPARATOR TUBE (SST/ GEL) OR PLAIN (RED TOP) VACUTAINER.

Sample volume

AT LEAST 2 ML

Rejection criteria

LABELING ISSUE (UNLABELED/ MISLABELED); MISSING REQUEST FORM; MISMATCH BETWEEN REQUEST FORM & SAMPLE DETAILS; MISSING AGE/ GENDER; WRONG SAMPLE TYPE; INSUFFICIENT SAMPLE.

Other Instructions

Reference intervals

AGE, GENDER & TANNER STAGE DEPENDENT.

Clinical Utility

DHT IS A POTENT TESTOSTERONE-DERIVED (VIA 5 ALPHA REDUCTASE) ANDROGEN. EVALUATION OF SUSPECTED MALE HYPOGONADISM (LOW LIBIDO, ERECTILE DYSFUNCTION, ETC.), 5-ALPHA REDUCTASE DEFICIENCY. EVALUATION OF VIRILIZATION & SUSPECTED HYPERANDROGENEMIA IN FEMALES.

Test Limitations/ Confounders

11 Jun

DEXAMETHASONE SUPPRESSION TEST (LOW DOSE – 1 MG OVERNIGHT) – CORTISOL

June 11, 2023June 11, 2023vincentochiengde

Category

SPECIAL CHEMISTRY.

Sub Category

ENDOCRINE

Synonyms/Aliases

DST SINGLE DOSE OVERNIGHT, CORTISOL

Abbreviations

1MG OVERNIGHT DST, CORTISOL

^Type

PROFILE/ PANEL (BUNDLED TESTS)

^Results

RESULTS READY/ REPORTED 7 WORKING DAYS

^Method

IMMUNOASSAY

^Temp

REFRIGERATED OR FROZEN.

^Setup

BATCHED.

Components Parameters

BASAL (PRE-DEXAMETHASONE) 8AM & POST DEXAMETHASONE 8AM CORTISOL LEVELS.

PRE-ANALYTIC CONSIDERATIONS

Test Ordering Instructions

Patient preparation

COLLECTION OF SAMPLES BEFORE & AFTER ADMINISTRATION OF DEXAMETHASONE IS DONE. IF THERE IS A CONCURRENT ORDER FOR 24 HOUR URINE CORTISOL LEVEL, THE COLLECTION OF 24 HOUR URINE MUST BE DONE PRIOR TO COMMENCING THIS TEST. A BASAL (PRE-DEXAMETHASONE) SAMPLE IS COLLECTED AT 8-9A.M. ON DAY 1. AT NIGHT (11P.M.-MIDNIGHT), THE PATIENT WILL TAKE THE PRESCRIBED DEXAMETHASONE. AT 8A.M. ON DAY 2, PATIENT WILL PRESENT HIMSELF FOR COLLECTION OF THE POST-DEXAMETHASONE SAMPLE.

Sample type

TWO SERUM SAMPLES [BASAL (PRE-DEXAMETHASONE; COLLECTED AT 8-9A.M. ON DAY 1) AND POST-DEXAMETHASONE (COLLECTED AT 8-9A.M. ON DAY 2 AFTER INGESTION OF DEXAMETHASONE BETWEEN 11P.M. AND MIDNIGHT)]. SAMPLE LABEL MUST INCLUDE COLLECTION SEQUENCE I.E. BASAL (PRE-DEXAMETHASONE) & POST-DEXAMETHASONE.

Container/ preservative

THREE SERUM SEPARATOR TUBES (SST/ GEL) OR PLAIN (RED TOP) VACUTAINERS.

Sample volume

AT LEAST 3 ML

Rejection criteria

LABELING ISSUE (UNLABELED/ MISLABELED/ COLLECTION SEQUENCE NOT STATED); MISSING REQUEST FORM; MISMATCH BETWEEN REQUEST FORM & SAMPLE DETAILS; MISSING AGE/ GENDER; WRONG SAMPLE TYPE; INSUFFICIENT SAMPLE.

Other Instructions

CENTRIFUGE SST (SERUM GEL TUBES) WITHIN 1-2 HOURS OF COLLECTION. CENTRIFUGE RED TOP VACUTAINERS AND ALIQUOT SERUM WITHIN 1-2 HOURS OF COLLECTION. THE SEPARATION VIAL MUST BE LABELED WITH AT LEAST 2 PATIENT IDENTIFIERS AND THE SAMPLE TYPE. WHERE MULTIPLE CORTISOL TESTS ARE CONCURRENTLY ORDERED I.E. A.M. CORTISOL, P.M. CORTISOL, 24 HOUR URINE CORTISOL & OVERNIGHT DST, PLEASE CONTACT THE PATHOLOGIST FOR CORRECT INSTRUCTIONS & COLLECTION SEQUENCE TO AVOID REPEAT COLLECTIONS &/ OR COMPROMISED RESULTS.

Reference intervals

INTERPRETIVE DATA IS PROVIDED ON THE REPORT.

Clinical Utility

THIS IS AN ENDOCRINE SUPPRESSION TEST USED WHEN SCREENING FOR CUSHING'S DISEASE OR CUSHING'S SYNDROME (HYPERSECRETION OF CORTISOL).

Test Limitations/ Confounders

INCORRECT LABELING OF COLLECTION SEQUENCE WILL RESULT IN INACCURATE INTERPRETATION. FALSE POSITIVE RESULTS MAY OCCUR DUE TO STRESS, DEPRESSION, ALCOHOLISM.

11 Jun

DEHYDROEPIANDROSTENEDIONE SULPHATE (DHEAS)

June 11, 2023June 11, 2023vincentochiengde

Category

SPECIAL CHEMISTRY.

Sub Category

ENDOCRINE

Synonyms/Aliases

DHEA SULPHATE; DHEA SULFATE

Abbreviations

DHEAS; DHEA-S; DHEA SO4

^Type

INDIVIDUAL TEST

^Results

RESULTS READY/ REPORTED 7 WORKING DAYS

^Method

IMMUNOASSAY

^Temp

REFRIGERATED OR FROZEN.

^Setup

BATCHED.

Components Parameters

IgG (SERUM & CSF), IgG RATIO (CSF IgG/ SERUM IgG), ALBUMIN (SERUM & CSF), ALBUMIN RATIO (CSF ALBUMIN/ SERUM ALBUMIN) & IgG INDEX (CSF/ SERUM IgG RATIO DIVIDED BY CSF/ SERUM ALBUMIN RATIO).

PRE-ANALYTIC CONSIDERATIONS

Test Ordering Instructions

FILL OUT TEST REQUEST FORM FULLY & LEGIBLY.

Patient preparation

SPECIFIC TIMING APPLIES I.E. TROUGH (PRE-DOSE; C0) OR TWO HOURS POST DOSE (C2) SAMPLE AS SPECIFIED BY THE ORDERING DOCTOR/ CLINICIAN.

Sample type

SERUM

Container/ preservative

SERUM SEPARATOR TUBE (SST/ GEL) OR PLAIN (RED TOP) VACUTAINER.

Sample volume

AT LEAST 2 ML

Rejection criteria

LABELING ISSUE (UNLABELED/ MISLABELED); MISSING REQUEST FORM; MISMATCH BETWEEN REQUEST FORM & SAMPLE DETAILS; MISSING AGE/ GENDER; WRONG SAMPLE TYPE; INSUFFICIENT SAMPLE.

Other Instructions

Reference intervals

AGE, GENDER & TANNER STAGE DEPENDENT.

Clinical Utility

DHEAS IS THE SULPHATED FORM OF DHEA WHICH IS AN ANDROGEN PRIMARILY PRODUCED IN THE ADRENAL CORTEX. ALONG WITH OTHER SEX STEROIDS, IT IS USEFUL IN EVALUATING HIRSUTISM & VIRILIZATION IN WOMEN, SUSPECTED TUMORS OF THE ADRENAL CORTEX, PRECOCIOUS PUBERTY IN BOYS & AS AN ADJUNCT IN SUSPECTED CONGENITAL ADRENAL HYPERPLASIA (CAH).

Test Limitations/ Confounders

11 Jun

DEHYDROEPIANDROSTENEDIONE

June 11, 2023June 11, 2023vincentochiengde

Category

SPECIAL CHEMISTRY.

Sub Category

ENDOCRINE

Synonyms/Aliases

UNCONJUGATED DHEA

Abbreviations

DHEA

^Type

INDIVIDUAL TEST

^Results

RESULTS READY/ REPORTED 7 WORKING DAYS

^Method

IMMUNOASSAY

^Temp

REFRIGERATED OR FROZEN.

^Setup

BATCHED.

Components Parameters

IgG (SERUM & CSF), IgG RATIO (CSF IgG/ SERUM IgG), ALBUMIN (SERUM & CSF), ALBUMIN RATIO (CSF ALBUMIN/ SERUM ALBUMIN) & IgG INDEX (CSF/ SERUM IgG RATIO DIVIDED BY CSF/ SERUM ALBUMIN RATIO).

PRE-ANALYTIC CONSIDERATIONS

Test Ordering Instructions

FILL OUT TEST REQUEST FORM FULLY & LEGIBLY.

Patient preparation

SPECIFIC TIMING APPLIES I.E. TROUGH (PRE-DOSE; C0) OR TWO HOURS POST DOSE (C2) SAMPLE AS SPECIFIED BY THE ORDERING DOCTOR/ CLINICIAN.

Sample type

SERUM

Container/ preservative

PLAIN (RED TOP) VACUTAINER. SERUM SEPARATOR TUBE (SST/ GEL) SHOULD BE AVOIDED.

Sample volume

AT LEAST 2 ML

Rejection criteria

LABELING ISSUE (UNLABELED/ MISLABELED); MISSING REQUEST FORM; MISMATCH BETWEEN REQUEST FORM & SAMPLE DETAILS; MISSING AGE/ GENDER; WRONG SAMPLE TYPE; INSUFFICIENT SAMPLE.

Other Instructions

CENTRIFUGE RED TOP VACUTAINERS AND ALIQUOT SERUM WITHIN 1-2 HOURS OF COLLECTION. THE SEPARATION VIAL MUST BE LABELED WITH AT LEAST 2 PATIENT IDENTIFIERS AND THE SAMPLE TYPE I.E. SERUM

Reference intervals

AGE, GENDER & TANNER STAGE DEPENDENT.

Clinical Utility

DHEA IS AN ANDROGEN PRIMARILY PRODUCED IN THE ADRENAL CORTEX. ALONG WITH OTHER SEX STEROIDS, IT IS USEFUL IN EVALUATING HIRSUTISM & VIRILIZATION IN WOMEN, SUSPECTED TUMORS OF THE ADRENAL CORTEX, PRECOCIOUS PUBERTY IN BOYS & AS AN ADJUNCT IN SUSPECTED CONGENITAL ADRENAL HYPERPLASIA (CAH).

Test Limitations/ Confounders

11 Jun

CYCLOSPORINE

June 11, 2023June 11, 2023vincentochiengde

Category

SPECIAL CHEMISTRY.

Sub Category

DRUGS/ TDM/ TOXICOLOGY

Synonyms/Aliases

CYCLOSPORIN

Abbreviations

C2 (CYCLOSPORIN 2 HOURS POST DOSE), C0 (CYCLOSPORINE TROUGH/ PREDOSE LEVEL)

^Type

INDIVIDUAL TEST

^Results

RESULTS READY/ REPORTED 7 WORKING DAYS

^Method

IMMUNOASSAY

^Temp

REFRIGERATED

^Setup

BATCHED.

Components Parameters

IgG (SERUM & CSF), IgG RATIO (CSF IgG/ SERUM IgG), ALBUMIN (SERUM & CSF), ALBUMIN RATIO (CSF ALBUMIN/ SERUM ALBUMIN) & IgG INDEX (CSF/ SERUM IgG RATIO DIVIDED BY CSF/ SERUM ALBUMIN RATIO).

PRE-ANALYTIC CONSIDERATIONS

Test Ordering Instructions

FILL OUT TEST REQUEST FORM FULLY & LEGIBLY. DETAILED SPECIFIC HISTORY IS REQUIRED E.G. EXACT INDICATION FOR DRUG MONITORING, DRUG HISTORY (I.E. DOSE, ROUTE OF ADMINISTRATION, DURATION SINCE TREATMENT WAS STARTED OR DOSE ADJUSTED, CONCURRENT MEDICATION), HEIGHT, WEIGHT. MUST SPECIFY WHETHER DRUG COLLECTION SHOULD BE DONE PRE-DOSE (C0) OR TWO HOURS POST DOSE (C2).

Patient preparation

SPECIFIC TIMING APPLIES I.E. TROUGH (PRE-DOSE; C0) OR TWO HOURS POST DOSE (C2) SAMPLE AS SPECIFIED BY THE ORDERING DOCTOR/ CLINICIAN.

Sample type

EDTA WHOLE BLOOD (MOST OF THE DRUG IS BOUND TO ERYTHROCYTES).

Container/ preservative

EDTA (PURPLE TOP) VACUTAINER

Sample volume

AT LEAST 3 ML

Rejection criteria

LABELING ISSUE (UNLABELED/ MISLABELED); MISSING REQUEST FORM; MISMATCH BETWEEN REQUEST FORM & SAMPLE DETAILS; MISSING AGE/ GENDER; WRONG SAMPLE TYPE (E.G. SERUM); INSUFFICIENT SAMPLE; MISSING HISTORY AS EXPOUNDED UNDER TEST ORDERING INSTRUCTIONS.

Other Instructions

NOT APPLICABLE

Reference intervals

INTERPRETIVE DATA IS PROVIDED ON THE REPORT.

Clinical Utility

OPTIMIZE DRUG DOSAGE (TO AVOID SUBTHERAPEUTIC & TOXIC DOSES I.E. ENSURE TARGET THERAPEUTIC RANGE IS ACHIEVED); TO VERIFY COMPLIANCE. CYCLOSPORINE IS AN IMMUNOSUPPRESSANT DRUG USED IN SOLID ORGAN TRANSPLANT RECIPIENTS.

Test Limitations/ Confounders

LEVELS ARE INFLUENCED BY DOSAGE REGIMEN, DRUG INTERACTIONS, INDIVIDUAL'S METABOLIZING CAPACITY, LIVER DYSFUNCTION.

11 Jun

CSF IgG INDEX

June 11, 2023June 11, 2023vincentochiengde

Category

SPECIAL CHEMISTRY.

Sub Category

FLUID ANALYSIS; INFLAMMATION

Synonyms/Aliases

CSF IgG INDEX PROFILE, SERUM & CEREBROSPINAL FLUID; CSF IMMUNOGLOBULIN G INDEX; IMMUNOGLOBULIN G, CSF INDEX; IMMUNOGLOBULIN G INDEX; IgG SYNTHESIS, CSF.

Abbreviations

-N/A

^Type

PROFILE/ PANEL (BUNDLED TESTS)

^Results

RESULTS READY/ REPORTED 7 WORKING DAYS

^Method

SPECTROPHOTOMETRY FOR SERUM ALBUMIN. NEPHELOMETRY OR IMMUNOTURBIDIMETRY FOR OTHER ANALYTES.

^Temp

REFRIGERATED OR FROZEN.

^Setup

BATCHED.

Components Parameters

IgG (SERUM & CSF), IgG RATIO (CSF IgG/ SERUM IgG), ALBUMIN (SERUM & CSF), ALBUMIN RATIO (CSF ALBUMIN/ SERUM ALBUMIN) & IgG INDEX (CSF/ SERUM IgG RATIO DIVIDED BY CSF/ SERUM ALBUMIN RATIO).

PRE-ANALYTIC CONSIDERATIONS

Test Ordering Instructions

FILL OUT TEST REQUEST FORM FULLY & LEGIBLY.

Patient preparation

NO PREPARATION REQUIRED.

Sample type

TWO SAMPLE TYPES CONCURRENTLY OBTAINED I.E. SERUM AND CSF (OR COLLECTED WITHIN THE SAME DAY).

Container/ preservative

SERUM SEPARATOR TUBE (SST/ GEL) OR PLAIN (RED TOP) VACUTAINER FOR SERUM COLLECTION. STERILE TUBE FOR CSF COLLECTION (IF A SERIES OF CSF TUBES ARE COLLECTED, SUBMIT TUBE 3).

Sample volume

2ML SERUM PLUS 2ML CSF.

Rejection criteria

LABELING ISSUE (UNLABELED/ MISLABELED); MISSING REQUEST FORM; MISMATCH BETWEEN REQUEST FORM & SAMPLE DETAILS; MISSING AGE/ GENDER; WRONG SAMPLE TYPE; INSUFFICIENT SAMPLE.

Other Instructions

NOT APPLICABLE

Reference intervals

INTERPRETIVE DATA IS PROVIDED ON THE REPORT.

Clinical Utility

USED TO CHECK INTEGRITY OF THE BLOOD BRAIN BARRIER (BBB) & FOR INFLAMMATORY DISEASES OF THE CENTRAL NERVOUS SYSTEM E.G. MULTIPLE SCLEROSIS, GBS, LUPUS CEREBRITIS, ENCEPHALITIS, TRANSVERSE MYELITIS, NEUROSYPHILIS WHICH ARE ASSOCIATED WITH INTRATHECAL IGG SYNTHESIS.

Test Limitations/ Confounders

INTRATHECAL IgG SYNTHESIS IS NOT SPECIFIC FOR MULTIPLE SCLEROSIS. CONSIDER TESTING FOR OLIGOCLONAL BANDS IF THERE IS A HIGH INDEX OF SUSPICION.

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